Resumo Objetivo Este artigo estuda o impacto das identidades sociais do empreendedor nos comportamentos de bootstrapping e o efeito de mediação das identidades sociais do empreendedor. Referencial teórico Este artigo utiliza a teoria da identidade social e a teoria effectuation como abordagem teórica. Metodologia Usamos regressões e modelos de equações estruturais com base em uma pesquisa com 365 empresas recém-criadas na Área Econômica e de Desenvolvimento de Hangzhou (HEDA) da China. Resultados Nossos resultados sugerem que os empreendedores com identidade darwiniana preferem o bootstrapping relacionado ao pagamento e o bootstrapping relacionado ao proprietário, enquanto aqueles com identidade missionária preferem o bootstrapping de utilização conjunta. O estudo empírico também constata que a causation medeia a relação entre identidades darwinianas e o bootstrapping relacionado ao pagamento, identidade social darwiniana e bootstrapping relacionado ao proprietário, identidade missionária e bootstrapping de utilização conjunta. Implicações práticas e sociais da pesquisa Ao explorar a influência da identidade social dos empreendedores nos comportamentos de bootstrapping e o efeito da mediação da lógica de tomada de decisão, este estudo pode ajudar os empreendedores a escolher comportamentos de bootstrapping adequados de acordo com sua identidade social correspondente. Contribuições Os resultados contribuem para a nossa compreensão dos fatores que impulsionam os comportamentos de bootstrapping de novos empreendimentos a partir da perspectiva da identidade social dos empreendedores e permitem uma forma mais rica e completa de explicar o comportamento de bootstrapping a partir da perspectiva da teoria da identidade. Os resultados também contribuem para a literatura sobre a relação entre identidade social dos empreendedores e comportamentos de bootstrapping, retratando e testando empiricamente os mecanismos de mediação da lógica de tomada de decisão neles.

Abstract Purpose This article studies the impact of entrepreneurs’ social identities on bootstrapping behaviors, and the mediation effect of the decision-making logic. Theoretical framework This article uses the theory of social identity and the theory of effectuation as its theoretical approach. Design/methodology/approach We used regressions and structural equation modeling based on a survey of 365 newly-created firms in China’s Hangzhou Economic and Development Area (HEDA). Findings Our findings suggest that entrepreneurs who have a Darwinian identity prefer payment-related bootstrapping and owner-related bootstrapping, while those who have a missionary identity prefer joint-utilization bootstrapping. The empirical study also finds that causation mediates the relationship between Darwinian identities and payment-related bootstrapping, Darwinian identities and owner-related bootstrapping, and missionary identities and joint-utilization bootstrapping. Practical & social implications of research By exploring the influence of entrepreneurs’ social identity on bootstrapping behaviors and the mediation effect of the decision-making logic, this study might help entrepreneurs choose suitable bootstrapping behaviors according to their corresponding social identity. Originality/value The findings contribute to our understanding of factors that drive the bootstrapping behaviors of nascent ventures from the perspective of entrepreneurs’ social identity, and they provide a richer and more complete way of explaining bootstrapping behavior from the perspective of identity theory. The findings also contribute to the literature on the relationship between entrepreneurs’ social identity and bootstrapping behaviors by depicting and empirically testing the mediation mechanisms of the decision-making logic.

Resumo Fundamento: A disfunção hepática é uma variável postulada de prognóstico desfavorável na cardiomiopatia dilatada (CMD). Objetivo: Este estudo teve como objetivo investigar o valor prognóstico do escore albumina-bilirrubina (ALBI), um modelo relativamente novo para a avaliação da função hepática, em pacientes com CMD idiopática. Métodos: Um total de 1.025 pacientes com CMD idiopática foram incluídos retrospectivamente e divididos em três grupos com base nos escores de ALBI: grau 1 (≤ −2,60, n = 113), grau 2 (−2,60 a −1,39, n = 835) e grau 3 (> −1,39, n = 77). Foi analisada a associação do escore ALBI com eventos clínicos adversos maiores (ECAM) intra-hospitalares e mortalidade a longo prazo. Valor de p inferior a 0,05 foi considerado estatisticamente significativo. Resultados: A taxa de ECAM intra-hospitalares foi significativamente maior nos pacientes com grau 3 (2,7% versus 7,1% versus 24,7%, p < 0,001). A análise multivariada mostrou que o escore ALBI foi um preditor independente para ECAM intra-hospitalares (odds ratio ajustada = 2,80, IC 95%: 1,63 – 4,80, p < 0,001). Após seguimento mediano de 27 meses, 146 (14,2%) pacientes morreram. A curva de Kaplan-Meier indicou que a taxa cumulativa de sobrevida a longo prazo foi significativamente menor em pacientes com grau mais alto de ALBI (log-rank = 45,50, p < 0,001). O escore ALBI foi independentemente associado à mortalidade a longo prazo (hazard ratio ajustada = 2,84, IC 95%: 1,95 – 4,13, p < 0,001). Conclusão: O escore ALBI, como modelo de risco simples, pode ser considerado uma ferramenta de estratificação de risco para pacientes com CMD idiopática.

Abstract Background: Liver dysfunction is a postulated variable for poor prognosis in dilated cardiomyopathy (DCM). Objective: This study aimed to investigate the prognostic value of the albumin-bilirubin (ALBI) score, a relatively new model for evaluating liver function, in patients with idiopathic DCM. Methods: A total of 1025 patients with idiopathic DCM were retrospectively included and divided into three groups based on ALBI scores: grade 1 (≤ −2.60, n = 113), grade 2 (−2.60 to −1.39, n = 835), and grade 3 (> −1.39, n = 77). The association of ALBI score with in-hospital major adverse clinical events (MACEs) and long-term mortality was analyzed. P-value less than 0.05 was considered statistically significant. Results: The in-hospital MACEs rate was significantly higher in the grade 3 patients (2.7% versus 7.1% versus 24.7%, p < 0.001). Multivariate analysis showed that ALBI score was an independent predictor for in-hospital MACEs (adjusted odds ratio = 2.80, 95%CI: 1.63 – 4.80, p < 0.001). After a median 27-month follow-up, 146 (14.2%) patients died. The Kaplan–Meier curve indicated that the cumulative rate of long-term survival was significantly lower in patients with higher ALBI grade (log-rank = 45.50, p < 0.001). ALBI score was independently associated with long-term mortality (adjusted hazard ratio = 2.84, 95%CI: 1.95 – 4.13, p < 0.001). Conclusion: ALBI score as a simple risk model could be considered a risk-stratifying tool for patients with idiopathic DCM.

Abstract Sangdu oral liquid (MFEC), a kind of traditional Chinese medicine, is used as a new immune enhancer for veterinary drugs or vaccines. In current study, we aimed to evaluate the effect and mechanism of MFEC on improving the immune response of B87 vaccine. Eighty SPF chickens were divided into blank control group (BC group), infectious bursal disease virus (IBDV) group (IBDV group), vaccine group (B87+IBDV group) and vaccine and Sangdu oral liquid combination group (MFEC+B87+IBDV group). In addition to the BC group, all other groups were infected with IBDV to establish immunosuppressive model. Chickens in both B87+IBDV and MFEC+B87+IBDV groups were immunized with B87 vaccine. Chickens in MFEC+B87+IBDV group were given MFEC for 7 days. Compared with B87+IBDV group, there were significantly lower morbidity and mortality, higher level of antibody, less tissue damage, lower expression of Bax and higher expression of Bcl-2 of MFEC+B87+IBDV group (P < 0.05). In MFEC+B87+IBDV group, the expression of IBDV-VP2, IL-6 and IFN-γ mRNA in bursal tissue was significantly lower than that in B87+IBDV group (P < 0.05). MFEC can effectively improve the immune response to B87 vaccine, and resist the invasion and replication of IBDV to avoid the tissue damage and apoptosis caused by IBDV infection.

The goal of this study was to identify potential transcriptomic markers in pediatric septic shock prognosis by an integrative analysis of multiple public microarray datasets. Using the R software and bioconductor packages, we performed a statistical analysis to identify differentially expressed (DE) genes in pediatric septic shock non-survivors, and further performed functional interpretation (enrichment analysis and co-expression network construction) and classification quality evaluation of the DE genes identified. Four microarray datasets (3 training datasets and 1 testing dataset, 252 pediatric patients with septic shock in total) were collected for the integrative analysis. A total of 32 DE genes (18 upregulated genes; 14 downregulated genes) were identified in pediatric septic shock non-survivors. Enrichment analysis revealed that those DE genes were strongly associated with acute inflammatory response to antigenic stimulus, response to yeast, and defense response to bacterium. A support vector machine classifier (non-survivors vs survivors) was also trained based on DE genes. In conclusion, the DE genes identified in this study are suggested as candidate transcriptomic markers for pediatric septic shock prognosis and provide novel insights into the progression of pediatric septic shock.

RESUMO: Tomando a província de Henan como exemplo, o sistema de índices de evasão rural foi construído a partir de três aspectos da economia, população e terra. Utilizando o método de peso de entropia, método de índice de vazamento, análise de autocorrelação espacial e Geo detector para analisar características de evolução espaço-temporal e fatores de influência do esvaziamento rural do município de 2000 a 2013 na província de Henan. Os resultados mostraram que a lacuna de esvaziamento rural entre condados na província de Henan foi expandida inicialmente e em seguida diminuiu, e toda a província estava no nível médio de evasão rural, e, além disso, o desenvolvimento da evasão rural na província de Henan era estável. As características de variação espacial de diferentes graus de evasão rural durante 2000-2013 eram óbvias, e o padrão espacial geral era mais alto na direção noroeste-sudeste e mais baixo na direção nordeste-sudoeste. Houve forte correlação positiva espacial no êxodo rural, e a aglomeração espacial foi levemente enfraquecida; o número de municípios nas áreas de aglomeração H-H e L-L era grande e as características de aglomeração eram óbvias; as áreas de aglomeração de H-L eram do zero com um pequeno número e distribuição dispersa. A influência de diferentes fatores no esvaziamento rural foi diferente, e a área de propriedade per capita, a proporção de indústrias secundárias e terciárias, o investimento em ativos fixos e a renda líquida per capita dos agricultores foram os fatores dominantes.

ABSTRACT: Taking Henan province as an example, the index system of rural hollowing was constructed from three aspects of economy, population and land. Using the entropy weight method, hollowing index method, spatial autocorrelation analysis and Geo detector, spatial-temporal evolution characteristics and influencing factors of county rural hollowing from 2000 to 2013 in Henan province were analyzed. Results showed that the gap of rural hollowing between counties in Henan province expanded first and then decrease, and the whole province was at the middle level of rural hollowing, so the development of rural hollowing in Henan province was stable and positive. Spatial variation characteristics of different degrees rural hollowing during 2000-2013 were obvious, and the overall spatial pattern was higher in the northwest-southeast direction and lower in the northeast-southwest direction. There was a strong spatial positive correlation in rural hollowing, and spatial agglomeration was slightly weakened; the number of counties in H-H and L-L agglomeration areas was large and its agglomeration characteristics were obvious; the H-L agglomeration areas started from zero with a small number and scattered distribution. Influence of different factors on rural hollowing was quite different, and the per capita homestead area, the proportion of secondary and tertiary industries, the investment in fixed assets and the per capita net income of farmers were the dominant factors.